The Apolipoprotein B concentration in Gingival Crevicular Fluid of Diabetes Mellitus Patients

Introduction Gingival crevicular fluid is exuded from the surrounding tissue of periodontal pockets in response to the pathogenic process in periodontitis. Gingival crevicular fluid contains microbial plaque, host inflammatory cells, host tissue and serumderived factors. As periodontal disease progresses, the volume of GCF increases and inflammatory cytokines appear in the GCF. GCF can be easily and non-invasively collected using dental paper points, so that it has been studied for clinical examinations. In particular, periodontal disease is considered to be one of the complications of diabetes mellitus (DM). Periodontitis is a chronic infectious disease affecting the tissues surrounding and supporting the teeth, caused by gram-negative bacteria in dental plaque. It is well established that patients with DM have at least a 2-fold increase in the risk of periodontal disease compared with non-diabetic subjects. Epidemiological studies have reported an association between periodontal disease and dyslipidemic conditions. Based on these we can hypothesize that Gingival crevicular fluid is a potentially a good substrate from which to estimate both the conditions of local gingival tissues and the systemic status.